The short version of heptapeptide fits in a sentence. The long version — which is the one that helps — is below.
This page was last updated on 2025-08-02 and is reviewed periodically as new material appears.
Development took place during the 1980s at institutes of the Russian Academy of Sciences, where peptide fragments of ACTH were screened for cognitive and neuroprotective effects. The compound received regulatory approval in Russia as a nasal preparation, marketed for conditions such as ischemic stroke, transient ischemic attacks, and optic nerve disorders. Registration in other countries has not followed. Most published clinical reports originate from a small number of Russian research groups, and independent replication outside that setting remains limited. The regulatory status therefore differs sharply between Russia and the rest of the world.
Laboratory work points toward modulation of neurotrophic signaling, particularly expression of brain-derived neurotrophic factor and nerve growth factor in hippocampal tissue. Studies also describe effects on monoamine turnover, inflammatory mediators, and oxidative markers. These observations come mainly from animal models and cultured cells, so the causal chain in humans is not firmly established. Whether the reported molecular changes translate into measurable clinical benefit is an open question. Reviews generally present the mechanism as plausible rather than demonstrated.
The parent fragment ACTH(4-10) carries the sequence Met-Glu-His-Phe-Arg-Trp-Gly. Semax replaces the arginine and tryptophan positions with a proline-glycine-proline tail, giving Met-Glu-His-Phe-Pro-Gly-Pro. That change removes residues associated with adrenal stimulation, so the peptide does not drive cortisol release the way full ACTH does. This distinction shapes how the compound is grouped in the literature, where it sits with neuropeptides and peptide neuromodulators rather than with corticosteroids.
Regulatory status varies sharply by country. Semax is registered for medical use in Russia, where it appears in formularies as a nasal solution, and it also holds registration in a small number of neighbouring states. It has no approval from the United States Food and Drug Administration or the European Medicines Agency, and it is not a scheduled controlled substance in most jurisdictions. Elsewhere it circulates mainly as laboratory material, so purity documentation comes from suppliers rather than from a national pharmacopoeia.
| Property | Value | Notes |
|---|---|---|
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro | Heptapeptide; ACTH(4-10) analog extended at C-terminus |
| Molecular mass | ~813.9 Da | Free peptide, unmodified |
| Appearance | White to off-white powder | Typical lyophilized solid |
| Solubility | Soluble in water and saline | Also soluble in common aqueous buffers |
| Storage (solid) | -20 °C, desiccated | Protect from moisture and repeated thawing |
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is described in the literature as an analogue of the ACTH(4–10) fragment, a short N-terminal portion of adrenocorticotropic hormone that retains some neurotropic activity without the full hormonal effects of the parent peptide. The molecule carries a methionine residue at the N-terminus and two proline residues near the C-terminus, features that shape both its interactions with receptor systems and its chemical stability. The free peptide corresponds to the formula C37H51N9O10S and a molecular mass near 813.9 Da.
The compound was developed in the 1980s at the Institute of Molecular Genetics in Moscow, where it emerged from research on short ACTH fragments and their effects on the central nervous system. Russian pharmaceutical listings describe it as a nootropic and neuroprotective agent, most often formulated as nasal drops. It is not a marketed medicine in the United States or the European Union, and no pharmacopoeial monograph covers it. Consequently, most published clinical experience with the substance originates from a small number of research centres, mainly in Russia and neighbouring countries.
Pharmacological accounts link semax to melanocortin signalling and to modulation of neurotrophic factor expression, particularly brain-derived neurotrophic factor and nerve growth factor. Much of this evidence comes from rodent studies using intranasal delivery, a route chosen because it allows peptides to reach the central nervous system with limited systemic exposure. Whether the same mechanisms operate in humans at comparable magnitude remains an open question. The precise receptor or receptors responsible for the reported behavioural and neuroprotective effects have not been conclusively identified.
The compound was developed during the 1980s at the Institute of Molecular Genetics in Moscow as part of research on fragments of adrenocorticotropic hormone. Early work examined short ACTH-derived sequences that retained neurotrophic effects while lacking the endocrine activity of the full hormone. Semax entered clinical use in Russia during the 1990s, where it received registration for several neurological indications. Outside that region it remained primarily a laboratory research material rather than an approved therapeutic. English-language literature on it grew more slowly and frequently cited the original Russian studies.
Terminology around the compound varies by source. It appears in catalogues and papers as Semax, as the heptapeptide ACTH(4-7)-Pro-Gly-Pro, and under various alphanumeric laboratory codes used by individual suppliers. These names refer to the same sequence but may imply different salt forms, purity grades, or counter-ions. Peptide databases usually list the free base mass, while product descriptions sometimes report acetate or trifluoroacetate salts with a different formula weight. Because naming conventions for research peptides are not standardised across vendors, checking the declared sequence and measured mass is more reliable than relying on a trade name alone.
=== Other types === Various types are distinguished by the domain of life to which they belong. Physical well-being concerns the domain of the body, including the capacity to engage in physical activity and the absence of illness and bodily pain. It includes general health considerations and the ability to perform one's social role without being hindered by physical limitations. Psychological well-being, also called mental health, is a state of mind characterized by internal balance. It involves the absence or successful management of disorders and disturbances, together with the abilities to cope with challenging situations, maintain positive relationships, and cultivate personal growth. It is closely linked to intellectual, spiritual, and emotional well-being. Intellectual well-being encompasses well-functioning cognitive abilities and traits, such as critical thinking, problem-solving, and curiosity. Spiritual well-being is a state in which people find purpose in life and have inner peace, self-confidence, and a sense of identity. Emotional well-being involves the capacities to comprehend, articulate, and regulate emotions, together with an overall positive mood. Hedonic well-being refers to a life rich in pleasurable experiences and devoid of suffering. Eudaimonic well-being is a form of personal fulfillment in which an individual flourishes by striving for excellence and actualizing their innate potential.
It is localized in the cytosol, but in response to high glucose it becomes glycosylated by OGT and/or phosphorylated by ERK, which causes translocation to the nucleus. In the nucleus β2 heterodimerizes with E47, binds to the E1 element of the insulin promoter and recruits co-activator p300 which acetylates β2. It is able to interact with other transcription factors as well in activation of the insulin gene. MafA is degraded by proteasomes upon low blood glucose levels. Increased levels of glucose make an unknown protein glycosylated. This protein works as a transcription factor for MafA in an unknown manner and MafA is transported out of the cell. MafA is then translocated back into the nucleus where it binds the C1 element of the insulin promoter. These transcription factors work synergistically and in a complex arrangement. Increased blood glucose can after a while destroy the binding capacities of these proteins, and therefore reduce the amount of insulin secreted, causing diabetes. The decreased binding activities can be mediated by glucose induced oxidative stress and antioxidants are said to prevent the decreased insulin secretion in glucotoxic pancreatic β cells. Stress signalling molecules and reactive oxygen species inhibits the insulin gene by interfering with the cofactors binding the transcription factors and the transcription factors itself. Several regulatory sequences in the promoter region of the human insulin gene bind to transcription factors.
In the United Kingdom, the Psychoactive Substances Act 2016 adopts a similar approach. Some countries, such as Australia, have enacted generic bans but based on chemical structure rather than psychoactive effect: if a chemical fits a set of rules regarding substitutions and alterations of an already-banned drug, then it too is banned. Brazil adopted the same model as Australia, in a recent ruling from ANVISA, which is responsible for defining what constitute drugs.
Recent Govt initiatives include digitalization of PACS,introduction of model by-laws for formation of new primary cooperatives,preference of cooperatives for common service center and jan aushadhi stores.Ministry of Cooperation has launched white revolution 2.0 for resilent milk production and procurement by cooperatives.
Sources: en.wikipedia.org
==== MeSH D08.211.211 – coenzyme a ==== MeSH D08.211.211.300 – acyl coenzyme a MeSH D08.211.211.300.075 – acetyl coenzyme a MeSH D08.211.211.300.500 – malonyl coenzyme a MeSH D08.211.211.300.700 – palmitoyl coenzyme a
=== Charles Hanani === Charles Hanani (Adam Levy) is Yasmin's father, and the wealthy CEO of the Hanani Publishing company. Charles is a serial philanderer, long divorced from Yasmin's mother Azar. He has a strained relationship with Yasmin, whom he treats like a child, and who carries trauma from growing up around her father's sexually inappropriate behavior. Charles reenters Yasmin’s life in series 2 when he arrives in London on business. Hoping to transition into Pierpoint’s private wealth management division, Yasmin brings him on as a client, only to learn that much of his fortune has been drained by nondisclosure settlements with women he had affairs with—including her former nanny, leading Yasmin to realize he likely groomed her. When confronted, Charles attacks Yasmin for condemning him while benefiting from his wealth and cuts her off financially. In series 3, Yasmin joins Charles on his yacht in Mallorca and catches him performing oral sex on a pregnant employee. Amid revelations that he is being sued by his own company for historic embezzlement, the two engage in a vicious confrontation in which Yasmin accuses him of sexualizing her throughout her life. A drunken Charles jumps overboard after Yasmin wishes him dead, and she makes no attempt to save him; Harper helps cover up her involvement. After Charles’ body is recovered, Hanani Publishing scapegoats Yasmin to deflect from its own complicity in silencing his victims, prompting her to sue the company.
Research and public pressure have led to bans on the use of Bisphenol A in bottles and cups to be used by children. In 2008 Walmart announced that it would stop selling baby bottles and food containers containing BPA. As of 2017, these were applied in at least 40 countries. Canada classified BPA as "toxic" in 2008 under the Canadian Environmental Protection Act. In 2011 use of bisphenol A in baby bottles was forbidden in all EU countries, in China, in Malaysia, and South Africa. In July 2012, the FDA stated that BPA would no longer used in baby bottles and sippy cups, in response to a petition from the American Chemistry Council stating that this was now in line with industry practice. Other countries such as Argentina and Brazil followed suit by prohibiting bisphenol A in baby bottles. Korea has extended its BPA ban to include all children's utensils, containers and packaging as of January 2020. There are calls for increased regulation of BPA in India.
== Medical use and research == Epothilone D, with the generic drug name utidelone, was approved in China in 2021 for the treatment of metastatic breast cancer. Utidelone has shown benefits in a phase III breast cancer trial when added to capecitabine. One synthetic analog, ixabepilone, was approved in October 2007 by the United States Food and Drug Administration for use in the treatment of aggressive metastatic or locally advanced breast cancer that no longer responds to currently available chemotherapies. In November 2008, the EMEA refused a marketing authorization for ixabepilone. Epothilone B, with the generic drug name patupilone, was proven to contain potent in vivo anticancer activities at tolerated dose levels in several human xenograft models. As a result, patupilone and various analogs underwent various clinical phases. Patupilone and the fully synthetic sagopilone were tested in phase II trials and BMS-310705 was tested in phase I trials). Patupilone failed a phase III trial for ovarian cancer in 2010. Results of a phase III trial with ixabepilone (BMS-247550) in combination with capecitabine in metastatic breast cancer have been announced (2007 – leading to FDA approval).
Modern works include Digby Gordon Seymour's Divided Loyalties: Fort Sanders and the Civil War (1963) and Robert McKenzie's Lincolnites and Rebels (2006). Knoxville's history from the end of the Civil War to the modern period is covered in Knoxville, Tennessee: Continuity and Change in an Appalachian City (1983), written by Michael McDonald and Bruce Wheeler, and subsequently expanded by Wheeler as Knoxville, Tennessee: A Mountain City in the New South (2005). Mark Banker's Appalachians All (2010) discusses the development of three East Tennessee communities, Knoxville, Cades Cove, and the Clearfork Valley (in Campbell and Claiborne counties). The history of Knoxville's African American community is covered in Robert Booker's Two Hundred Years of Black Culture in Knoxville, Tennessee: 1791 to 1991 (1994). Booker's The Heat of a Red Summer: Race Mixing, Race Rioting in 1919 Knoxville (2001) details the Riot of 1919. Merrill Proudfoot's Diary of a Sit-In (1962) provides an account of the 1960 Knoxville sit-ins. A significant portion of Charles Cansler's Three Generations: The Story of a Colored Family in Eastern Tennessee (1939) takes place in Knoxville. Native Knoxvillian James Herman Robinson describes his childhood in Knoxville in his autobiography, Road Without Turning (1950). Since the early 1990s, Metro Pulse editor Jack Neely has written numerous articles (often for his column, "The Secret History") that recall some of the more colorful, odd, obscure, and forgotten aspects of the city's history.
Sources: en.wikipedia.org
Pharmacological screens to identify endogenous channels and pumps responsible for specific patterning events; Voltage-sensitive fluorescent reporter dyes and genetically encoded fluorescent voltage indicators for the characterization of the bioelectric state in vivo. Panels of well-characterized dominant ion channels that can be misexpressed in cells of interest to alter the bioelectric state in desired ways; and Computational platforms that are coming on-line to assist in building predictive models of bioelectric dynamics in tissues. Compared with the electrode-based techniques, the molecular probes provide a wider spatial resolution and facilitated dynamic analysis over time. Although calibration or titration can be possible, molecular probes are typically semi-quantitative, whereas electrodes provide absolute bioelectric values. Another advantage of fluorescence and other probes is their less-invasive nature and spatial multiplexing, enabling the simultaneous monitoring of large areas of embryonic or other tissues in vivo during normal or pathological pattering processes.
=== Facilities === The Kwekwe Sports Club square has space for 5 pitches, the centre of which is used only for First Class games. The dimensions of the playing field vary depending on the game being played. For First Class games, the boundary extends to 75 yards straight down on the pitch and 71 yards square of the wicket. The boundaries are reduced for List A, Twenty20 and club cricket. The practice facilities at the ground are among the best in the country. There are 16 grass nets used for practice that run in an unusual east–west direction. There are also 3 artificial turf nets that are used primarily for throw downs and training on bowling machines.
Su ji (素鸡, "vegetarian chicken"), either by being rolled up or by being pressed together and fried. Baiye jie (百叶结 "baiye knots"), by slicing into 2 cm × 10 cm slices and tying the slice up. Various dishes that roll other food items inside a piece of baiye.
An example of a very simple tray is a perforated tray. The desired contacting between vapor and liquid occurs as the vapor, flowing upwards through the perforations, comes into contact with the liquid flowing downwards through the perforations. In current modern practice, as shown in the adjacent diagram, better contacting is achieved by installing bubble-caps or valve caps at each perforation to promote the formation of vapor bubbles flowing through a thin layer of liquid maintained by a weir on each tray. To design a distillation unit or a similar chemical process, the number of theoretical trays or plates (that is, hypothetical equilibrium stages), Nt, required in the process should be determined, taking into account a likely range of feedstock composition and the desired degree of separation of the components in the output fractions. In industrial continuous fractionating columns, Nt is determined by starting at either the top or bottom of the column and calculating material balances, heat balances and equilibrium flash vaporizations for each of the succession of equilibrium stages until the desired end product composition is achieved. The calculation process requires the availability of a great deal of vapor–liquid equilibrium data for the components present in the distillation feed, and the calculation procedure is very complex. In an industrial distillation column, the Nt required to achieve a given separation also depends upon the amount of reflux used.
Sources: en.wikipedia.org
Semax is a synthetic seven-amino-acid peptide derived from a fragment of corticotropin. It is used in Russia as a nasal preparation, while elsewhere it is studied as a research compound. It is not approved as a medicine in most countries.
Its sequence corresponds to the 4-10 region of corticotropin extended by three residues. This fragment lacks the region responsible for adrenal steroid release, so it is explored for neural rather than hormonal effects. The relationship explains the compound's classification among ACTH-derived peptides.
It holds approval in Russia for several neurological indications as a nasal spray or drop formulation. Regulatory agencies in the United States and the European Union have not approved it. Products sold elsewhere are generally labeled for research use only.
Registered medical products are most often 0.1% nasal drops. Research suppliers ship lyophilized powder, usually in milligram quantities, which is dissolved before use. The active peptide is the same in both cases; presentation and excipients differ.